Irf3 knockout mice
WebThe Irf3 gene (NCBI Reference Sequence: NM_016849 ; Ensembl: ENSMUSG00000003184 ) is located on mouse chromosome 7. Eight exons are identified, with the ATG start codon in exon 2 and the TGA stop codon in exon 8 (Transcript: ENSMUST00000003284). Exon 3~6 will be selected as target site. Cas9 and gRNA will be co-injected into fertilized eggs for … WebJun 5, 2024 · The IRF3 knockout (KO) mice develop obesity, insulin resistance, glucose intolerance, and eventually type 2 diabetes with aging, which is associated with the …
Irf3 knockout mice
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WebBackground: Malignant pleural mesothelioma (MESO) has a poor prognosis despite aggressive treatment with surgery, radiation and chemotherapy, and novel therapeutic approaches are needed. IRF3 is a downstream molecule of the cGAS/STING signaling pathway, but its roles have not been investigated in MESO. Methods: Various murine … WebNov 4, 2024 · Recent studies have suggested that STING signaling is necessary for the anticancer immune response based on the following observations: on the one hand, STING knockout mice and IRF3 knockout mice show impaired spontaneous T-cell responses against tumors [34, 35]; on the other hand, STING agonists show a favorable effect in …
WebAged WT and IRF3-KO mice were subject to CLP to induce sepsis, and a second group of aged WT mice were subject to sham surgery as a control. Graphs show pooled male and female data (n=10/group CLP, n=5/group sham) for (A) serum IL-6, (B) serum IL-12/23p40, (C) serum MCP-1. This cohort was split into male and female subgroups to show the …
http://www.informatics.jax.org/marker/MGI:1859179 WebNov 7, 2024 · IRF3 is a downstream molecule of the cGAS/STING signaling pathway, but its roles have not been investigated in MESO. Methods: Various murine mesothelioma cell lines were inoculated into wild type (WT) and IRF3 knockout …
WebApr 20, 2024 · Further analysis showed increased phosphorylated levels of IRF3 (pIRF3) in HFD-fed mice. HFD-fed IRF3-knockout mice showed reduced obesity-induced hepatic steatosis and improved insulin...
WebMar 9, 2024 · IRF3 interacts with IKKbeta in the cytoplasm to inhibit IKKbeta/NF-kappaB signaling, thus alleviating hepatic inflammation, insulin resistance, and hepatic steatosis. … small construction companies in sri lankaWebAged WT and IRF3-KO mice were subject to CLP to induce sepsis, and a second group of aged WT mice were subject to sham surgery as a control. Graphs show pooled male and … small construction companies in usaWeb036260 B6(SJL)- Irf3 tm1.1Evdr /J Irf3 fl mice have loxP sites flanking exons 3-6 of the interferon regulatory factor 3 gene. Exposure to Cre recombinase removes the floxed … some uses of mineralsWebFeb 8, 2024 · IRF3 Deficiency Increases Resistance to P. aeruginosa Infection in Mice. It has been previously reported that IRF3 increases the recruitment of neutrophils and facilitates pathogen clearance in the lungs of P. aeruginosa-infected mice [].To determine whether IRF3 is involved in survival and mortality, WT and IRF3 KO mice were injected with P. … small constricted pupilsWebFeb 11, 2024 · Adipocyte-specific knockout of Irf3 attenuates HFD-induced obesity in mice and increases insulin sensitivity. To assess the metabolic consequences of IRF3 … some vacation getaways crosswordWebNov 11, 2024 · Knockout or knockdown of OTUD4 impairs RNA virus-triggered activation of IRF3 and NF-κB, expression of their downstream target genes, and potentiates VSV replication in vitro and in vivo. Consistently, Cre-ER Otud4fl/fl or Lyz2-Cre Otud4fl/fl mice produce decreased levels of type I interferons and proinflammatory cytokines and exhibit ... small construction companies in houstonWebJul 30, 2015 · Furthermore, LPS-induced nucleosome remodeling at these promoters was completely eliminated in macrophages from IRF3 knockout mice, confirming a critical role for IRF3 in nucleosome remodeling. Nucleosome remodeling is in fact a more critical step towards selective regulation of gene activation than cooperative binding of transcription … small construction company structure