Photocatalytic α-arylation of cyclic ketones
WebJun 24, 2024 · 姓 名：易兵 职 称：教授 办公电话：0731-58683888 办公地点：新校区电气楼-307 电子邮件：[email protected]个人简介易兵，男，汉族，1970年生，湖南湘乡人，中共党员，博士，二级教授，博士生导师，湖南工程学院校长，校学术委员会主任。教育部大学化学课程教学指导委员会委员，湖南省普通高等学校 ... WebA combination of visible light photocatalysis and gold catalysis provides an entry into functionalized cyclic ketones from the coupling reaction of alkenyl and allenyl cycloalkanols with aryl diazonium salts via ring expansion-oxidative arylation. A mechanism involving generation of an electrophilic gold (III)-aryl intermediate is proposed.
Photocatalytic α-arylation of cyclic ketones
Did you know?
WebNov 22, 2013 · Experimental evidence indicates that two discrete reaction pathways can be operable in this process depending upon the nature of the ketyl radical precursor and the … WebEnantioselective α-Arylation of Ketones via a Novel Cu(I)–Bis(phosphine) Dioxide Catalytic System. Journal of the American Chemical Society 2024, 143 (9) , 3289-3294.
WebJul 14, 2024 · Ketones serve as one of the most critical building blocks in organic synthesis, involving numerous functional group transformations. Herein, we report an unprecedented photoredox–nickel metallaphotoredox-catalyzed decarboxylative acylation of common aliphatic acids with readily available aromatic and aliphatic thioesters. WebAug 20, 2024 · The direct α-arylation of unactivated carbonyl compounds using aryl halides represents a powerful method to synthesize criti-cal building blocks for diverse useful …
WebDOI: 10.1021/ja993912d ) has developed highly active and selective catalysts for the α-arylation of ketones. These consist of electron-rich phosphine ligands containing a biphenyl skeleton that are combined with the palladium complex … WebDec 1, 2024 · Challenging macrolactones can now be modularly assembled through a photocatalytic aerobic oxidative ring expansion of cyclic ketones. With the assistance of …
WebFeb 3, 2024 · Fig. 1: Photoredox activation for the α-arylation of cyclic ketones. a, Important bioactive natural products and drug molecules containing an α-arylated cyclic ketone core. b, Left: Existing ...
WebApr 10, 2024 · Aryl chlorides serve as both cross-coupling partners and the chlorine radical source for the α-oxy C(sp3)-H arylation of cyclic and acyclic ethers. Mechanistic studies suggest that photolysis of a Ni(III) aryl chloride intermediate, generated by photoredox-mediated single-electron oxidn., leads to elimination of a chlorine radical in what amts ... how to study productivelyWebA combination of visible light photocatalysis and gold catalysis provides an entry into functionalized cyclic ketones from the coupling reaction of alkenyl and allenyl cycloalkanols with aryl diazonium salts via ring expansion-oxidative arylation. A mechanism involving generation of an electrophilic gold (III)-aryl intermediate is proposed. reading exolorer答案WebFeb 26, 2015 · Here we report the direct asymmetric amination of α-substituted cyclic ketones catalyzed by a chiral phosphoric acid, yielding products with a N-containing quaternary stereocenter in high yields and excellent enantioselectivities. how to study poker rangesWebAbstract. Nickel-catalyzed asymmetric α-heteroarylation of ketones with fluorinated heteroarenes is reported via C–F bond activation. A series of ketones and 2-fluoropyridine derivatives with different functional groups proceed well to provide the corresponding products containing all-carbon quaternary stereocenters in good yields (up to 99% yield) … reading experience essayWebIn chemistry, photocatalysis is the acceleration of a photoreaction in the presence of a photocatalyst, the excited state of which "repeatedly interacts with the reaction partners … how to study physics in one dayWebHighly E- and Z-Selective Hydrogenation of Alkynes Using Chromium and Cyclic Carbene Ligands Full Text HTML PDF (142 kb) ... –H Arylation in the γ-Position of Sulfamate Esters and Amides Full Text HTML ... Aldol-Type Reaction of α,α-Difluoromethyl Ketones Catalyzed by an Organosuperbase Full Text HTML PDF (88 kb) ... how to study polishWebAug 31, 2024 · Further studies by the Doyle group established the α-oxy C(sp 3)−H arylation of cyclic and acyclic ethers 9 with aryl chlorides 8 under photoredox nickel catalysis . Here, aryl chlorides 8 serve as cross-coupling partners and the chlorine radical source, which rapidly abstracts an α-oxy C(sp 3 )−H of the ethers to form the key α-oxyalkyl ... how to study programming effectively