WebBacterial 2-hybrid screening with RING105 as bait revealed an interaction with TSSC5, which, like RING105, localized to cytoplasmic membranes. Immunoprecipitation and immunoblot analyses with truncated forms of TSSC5 demonstrated that TSSC5 was polyubiquitylated on its sixth hydrophilic loop in an accelerated manner in the presence of RING105 and UBCH6. WebORCTL2 (organic cation transporter-like protein 2), also known as HET, ITM, BWR1A, IMPT1, TSSC5, BWSCR1A, SLC22A1L, p45-BWR1A or SLC22A18, is a 424 amino acid multi-pass membrane protein that localizes at the apical membrane surface of renal proximal tubules. ORCTL2 is expressed at high levels in the kidney, ...
Somatic mutation of TSSC5, a novel imprinted gene from human …
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ORCTL2 (L395) polyclonal antibody-Primary Antibodies-Bioworld ...
WebSLC22A18 is a member of the family of polyspecific organic-cation transporters that localize at the apical membrane surface of renal proximal tubules. SLC22A18 is expressed at high levels in the kidney, liver, colon and in fetal renal proximal tubules and present at lower levels in heart, brain and lung. Defects in SLC22A18 are associated with ... WebThree of these genes (TSSC5, H19, and SNRPN) had normal monoallelic expression levels, and IGF2 had a partially relaxed imprinting pattern comparable to levels found in normal somatic cells. This study also determined that the imprinting control region that regulates H19 and IGF2 imprinting had a normal pattern of DNA methylation. WebMay 26, 2009 · A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. See also. how tall is a 5 year old girl